Abstract
Sensitivity of 5-bromouracil-treated ( 5-BU-treated) pol + and pol A1 bacteria to UV light, methyl methanesulfonate (MMS), 4-nitroquinoline 1-oxide ( 4-NQO), thymine starvation (TS) and mitomycin C (MC) was studied. It was shown that 5-BU sensitization to UV light is almost independent of Pol phenotype. Strain pol A1 is more sensitive to 5-BU sensitization to 4-NQO, MMS and TS but is less sensitive to 5-BU sensitization to MC. Presented data suggest that at least three kinds of damages can be induced in 5-BU-containing DNA of bacteria treated with such agents as ( i) UV light (probably single-strand breaks unrepairable by DNA polymerase); ( ii) 4-NQO, MMS, TS (probably single-strand breaks repairable by DNA polymerase); and ( iii) MC (damages which probably are not single-strand breaks, and the nature of which is unclear).
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