479. Expression of the apoptosis inhibitors p53, bcl-2, EGFR and survivin in renal cell carcinomas: Correlation with pathological features and clinical outcome

Abstract

S S181 479. Expression of the apoptosis inhibitors p53, bcl-2, EGFR and survivin in renal cell carcinomas: Correlation with pathological features and clinical outcome J. Contis, P. Lykoudis, C. Nastos, A. Karakatsanis, D. Dellaportas, A. Delis, D. Karandrea, A. Pafiti-Kondi 1 University of Athens Medical School, 2nd Dept. of Surgery, Athens, Greece University of Athens Medical School, Pathology, Athens, Greece Introduction: Survivin is a member of the inhibitors of the apoptosis (IAP) family. Over expression of survivin has been found in most human cancers and has been associated with poor prognosis. We studied the prognostic significance of the apoptosis inhibitors survivin, p 53, bcl-2, EGFR in renal cell carcinomas and correlated their expression with pathologic features and overall survival. Material and methods: 78 renal cell carcinomas were retrospectively assessed by immunohistochemistry for survivin, p53, bcl-2 and EGFR expression. Gender, age, size, histological type and grade of tumor as well stage were recorded, while survival data were retrieved from the follow-up records of the patients. Statistical analysis of the above data was carried out. Results: 52 male and 26 female patients aged from 35 to 87 years (median 66 years) were included.Mean tumor diameter was 6.8 cm and themost common location was the upper left kidney. Clear cell adenocarcinoma was observed in 77% of case, granular type in 14%, spindle cell type in 6% and papillary type in 3%of the cases. 16%of the tumorswere grade 1, 56%grade 2 and 18%were grade 3. Survivin expressionwas detected in 59 (76%) cases, bcl-2 in 64% of cases, p53 in 82% of cases and EGFR in 54% of cases. Statistical analysis showed that p53, survivin and tumor stage but not bcl-2 and EGFR status were significantly related to survival. Cox regression analysis showed that survivin expression was an independent prognostic factor for RCC and was associated with a poorer prognosis. Conclusions: Our study suggests that survivin is an independent prognostic factor of overall survival in renal cell carcinomas and this finding may indicate a need for adjuvant therapy for high-risk patients. No conflict of interest. http://dx.doi.org/10.1016/j.ejso.2014.08.485