Abstract
For locally advanced rectal cancer (LARC) patients who achieved complete clinical response (cCR) after neoadjuvant chemoradiotherapy (nCRT), a “Watch & Wait” (W&W) approach is adopted to improve quality of life. However, W&W may increase the recurrence risk of those who are not pathological complete response (non-pCR). Cell-free DNA (cfDNA) end motifs have been used in cancer detection. But its utility in predicting pCR status has not been reported. In this study, we explored the potential of cfDNA end motif profile in the prediction of pathological response in LARC patients.
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