Abstract

Chromosomal microarray analysis (CMA) can identify submicroscopic pathogenic copy number changes (CNC) that are too small to be detected by standard chromosome analysis. The American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine recommends use of CMA for prenatal diagnosis of fetuses with one or more major structural abnormalities identified on ultrasound, or for evaluation of intrauterine fetal death or stillbirth.

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