43. The Association Between Triglyceride-Glucose Index and Incidence of Hypertension: A Systematic Review and Dose-Response Meta-analysis

Abstract

Background: Theoretically, insulin resistance and hypertension were shown to be closely related. Therefore, as the triglyceride-Glucose (TyG) index is one of the surrogate markers of insulin resistance, this meta-analysis aims to evaluate the dose-response relationship between the TyG index and hypertension. Methods: We performed a systematic literature search using PubMed, Scopus, Embase, and Science Direct until January 2023. The exposure was the TyG index, and the outcome of interest was the incidence of hypertension across the TyG index intervals. The effect estimate was reported as odds ratios (ORs) in unadjusted and adjusted model. Adjusted odds ratios were carried out from all included studies in order to eliminate the possibility of confounding factors being involved in the incidence of hypertension. Results: A total of 205.835 participants (mean age: 48 years old, male sex: 46%, mean BMI: 24.6 kg/m2) from 11 observational studies were included in this meta-analysis. This meta-analysis showed that the highest category of TyG index was associated with increased risk for hypertension in unadjusted (OR = 3.01 [1.97, 4.61], p < 0.001; I2: 99.1%, p < 0.001) and adjusted model (OR = 1.63 [1.25, 2.13], p < 0.001; I2: 95.5%, p < 0.001). The linear association showed a statistically non-significant trend for every 0.5 increase in the TyG index (OR 1.40 [0.63, 3.13], p = 0.413). Dose-response meta-analysis showed that the relationship between the TyG index and hypertension was non-linear (p < 0.001). Furthermore, statistical significance was obtained when the TyG index reached around 8.3 and increased non-linearly. Conclusion: TyG index was significantly associated with hypertension in a non-linear dose-response relationship.