Abstract
This chapter focuses on ultra centrifugation. Proteins were the first high-molecular compounds to be studied with the ultracentrifuge. The usefulness of ultracentrifugation has steadily increased and presently, the ultracentrifuge is an indispensable research instrument in almost all protein investigations. It is a well-known fact that the weight of a particle is related to its rate of sedimentation in a gravitational field. To use this method for measurements of molecular weights it is necessary to employ very high fields of force, the weight of a single molecule being so small and the sedimentation rate being proportional both to the particle weight and the force of the field. Such high fields of force may be achieved in centrifugal fields. The best developed motor-driven ultracentrifuges presently have a resolving power that is at least as high as that of the original oil-turbin centrifuges that are gradually getting out of use.
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