4. Re-Evaluation of Clinico-Histopathological Determination on Malignancy, on the Evidence of Exaggerated Survery over the Entire Polyps, in Two Cases of Familial and Non-Familial Diffuse Colonic Polyposis with Partial Malignant Changes

Abstract

In order to re-analyze the quality (anaplasia)—quantity (dimension, portion)—interrelationship in judging malignancy for final diagnosis, an exaggerated histological survey throughout the entire polyps of 920 pieces in a familial and of 2, 333 pieces in a non-familial diffuse colonic polyposis with partial malignant transformation was attempted with special remarks on borderline type (carcinoma in situ).Some notes were drawn from the consideration of correlation among the polyp site, their sizes and the atypism. Only one unquestoinable polyp-carcinoma in each case was found in rectum and S-romanum, respectively.On the basis of the exhaustive observation over the whole polyps with their quality-quantity relations, the control of subjective (personal or individual) factors is prepossessed for discrepancy between histological dicision (a doctrine) and an undetermined aspect of each polyp (a real existence).Thus, a simple classification of cancer or non-cancer group, abandonning the grading system I to V, practically contributory toward clinical fields was newly proposed after the elucidation of our criteria.