Abstract
Investigations of T cell receptor (TCR) repertoire diversity have contributed to our current understanding of the post-transplant effects on T cell populations of antigen-driven peripheral expansion and thymic-dependent immune reconstitution. Spectratyping, the RT-PCR based assessment of variation in the lengths of the complementarity determining region 3 (CDR3) of the TCR BV families, has been widely used to define oligoclonal, skewed and polyclonal Gaussian-like repertoire diversity. The limited levels of circulating T cells following transplantation have, however, limited the use of this technique on clinically available samples.
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