377 PATHOLOGICAL RESULTS IN PATIENTS ELIGIBLE FOR SIX INTERNATIONAL ACTIVE SURVEILLANCE PROTOCOLS

Abstract

You have accessJournal of UrologyProstate Cancer: Localized I1 Apr 2012377 PATHOLOGICAL RESULTS IN PATIENTS ELIGIBLE FOR SIX INTERNATIONAL ACTIVE SURVEILLANCE PROTOCOLS Albert El Hajj, Guillaume Ploussard, Camelia Radulescu, Aude Defourmestraux, Norman Gillion, Andras Hoznek, Dimitri Vordos, Rene Yiou, Yves Allory, Alexandre de la Taille, Clement Claude Abbou, and Laurent Salomon Albert El HajjAlbert El Hajj Paris, France More articles by this author , Guillaume PloussardGuillaume Ploussard Paris, France More articles by this author , Camelia RadulescuCamelia Radulescu Paris, France More articles by this author , Aude DefourmestrauxAude Defourmestraux Paris, France More articles by this author , Norman GillionNorman Gillion Paris, France More articles by this author , Andras HoznekAndras Hoznek Paris, France More articles by this author , Dimitri VordosDimitri Vordos Paris, France More articles by this author , Rene YiouRene Yiou Paris, France More articles by this author , Yves AlloryYves Allory Paris, France More articles by this author , Alexandre de la TailleAlexandre de la Taille Paris, France More articles by this author , Clement Claude AbbouClement Claude Abbou Paris, France More articles by this author , and Laurent SalomonLaurent Salomon Paris, France More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.440AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Our objective was to analyze the pathological results of patients undergoing radical prostatectomy (RP) who were eligible for 6 international active surveillance protocols. METHODS From 2001 to 2011, 1161 patients underwent RP after being diagnosed with an extended 21 core biopsy protocol. We evaluated the pathological results for upgrading (Gleason>6), upstaging (>T2) and significant tumor (Gleason>6 and/or >T2) for patients who had the active surveillance criteria of the University of Toronto, Royal Marsden, John Hopkins, UCSF, MSKCC and PRIAS. (Table). Inclusion criteria of active surveillance protocols Protocol Nb of Patients (%) Gleason Score PSA PSAD Clinical Stage Positive Biopsies % single core involvement University of Toronto 485(41.7) ≤ 3+4 ≤ 15 - T1/T2 ≤ 3 ≤ 50% Royal Marsden 796(68.6) ≤ 7 ≤ 20 - T1/T2 - - John Hopkins 191(16.4) ≤ 6 - ≤ 0.15 T1 ≤ 2 ≤ 50% UCSF 395(34) ≤ 6 ≤ 10 - T1/T2 ≤ 1/3 of biopsies ≤ 50% MSKCC 830(71.5) ≤ 7 - - T1/T2 - - PRIAS 306(26.3) ≤ 6 ≤ 10 ≤ 0.2 T1/T2 ≤ 2 - RESULTS MSKCC and Royal Marsden protocols were the least selective with 830 (71.5%) and 796 (68.6%) while only 191 patients (16.4%) were eligible for John Hopkins' criteria. (Table) Upgrading varied from 38% (MSKCC) to 50.6% (UCSF) and upstaging from 14.6% (John Hopkins) to 27% (Toronto). (Fig 2). SVI was noted in 17 patients (3.5%) in the university of Toronto group. The rate of significant tumor at RP varied from 40% (MSKCC) to 52.7% (UCSF). CONCLUSIONS Active surveillance protocols that are more stringent for number of positive biopsies and percentage of single cores' involvement, have a less than 15% risk of upstaging. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e154 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Albert El Hajj Paris, France More articles by this author Guillaume Ploussard Paris, France More articles by this author Camelia Radulescu Paris, France More articles by this author Aude Defourmestraux Paris, France More articles by this author Norman Gillion Paris, France More articles by this author Andras Hoznek Paris, France More articles by this author Dimitri Vordos Paris, France More articles by this author Rene Yiou Paris, France More articles by this author Yves Allory Paris, France More articles by this author Alexandre de la Taille Paris, France More articles by this author Clement Claude Abbou Paris, France More articles by this author Laurent Salomon Paris, France More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...