Abstract
Hypoxia inducible factor-1 (HIF-1) is a transcription factor promoting transcription of various downstream genes involved in cytoprotection, anti-inflammation and proliferation. HIF-1 is stabilized in hypoxia, whereas in normoxia HIF-1 is rapidly degraded via anti-oncogene Von hippel lindau (VHL) protein. The aim of this study was to investigate acute rejection in recipient with HIF-1α-deletions (no HIF-1 activity) or VHL-deletions (constitutively stable HIF-1 activity) in granulocytes and monocytes/macrophage lineage in normoxic conditions.
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