Abstract
Researchers previously regarded ribosomes as static and identical molecular machines within cells. In recent years the discovery of heterogeneous ribosomes challenged this simplified view. Heterogeneous ribosomes may differ in rRNA, ribosomal protein composition, or differential modifications of ribosomal proteins or rRNA. However, the functional consequences of these structural specializations are still poorly understood. The presence of senescent cells in vivo is associated with several age-related changes.
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