(345) The Pathophysiology of Peyronie’s Disease Following Radical Prostatectomy

Abstract

Abstract Introduction Peyronie’s disease (PD) is defined as a fibrotic disease of the penis resulting in plaque formation and abnormal penile curvature. In the general population the incidence of PD is 0.7%, however, this increases to 16% after radical prostatectomy (RP). Objective Our aim is to document the incidence of PD after radical prostatectomy seen in our hospital. Methods A prospective and a retrospective audit recruiting men undergoing RP. Both documented demographics, operative details and PD risk factors. The retrospective audit has reviewed men undergoing a RP in 2018. After identification the patients were contacted to clarify any development of curvature after RP. The prospective audit has reviewed men prior to their RP with an IIEF, PD questionnaires and examinations for existing plaques. Then again at 6 weeks, 3 months and 6 months post-operatively. Results For the retrospective audit; 511 men were identified, of which 194 were recruited. Of these 16% (n=31) described a new curvature. 7 were Non-Nerve Sparing (NNS), 11 Unilateral Nerve-Sparing (UNS) and 13 Bilateral Nerve-Sparing (BNS). These had a mean curvature of 20 degrees (SD=8). For the prospective audit; 524 men have joined the study of which 267 have had their 6-month review. 47% (n=126) of those reaching 6 months post-op had a new plaque. 29 were NNS, 39 UNS (14 intra-facial: extra-facial and 25 inter-facial: extra-facial) and 58 BNS (30 intra-facial: intra-facial), 18 intra-facial: inter-facial and 10 inter-facial: inter-facial). Conclusions These are ongoing audits which still require further investigation. However, a larger proportion of men than thought develop a new plaque. The retrospective study collaborates the previous indicated 16% of new PD diagnoses after RP. Disclosure No