Abstract
In the title compound, C26H24BrN3O2, the isoxazolidine ring adopts an envelope conformation, the ring N atom deviating from the mean plane of the other four atoms by an angle of 0.286°. The orientation of the phenyl ring is +sp and the bromophenyl ring is +sc relative to the attached pyrazole ring; the dihedral angles between the least-squares planes of the pyrazole and the attached phenyl and bromophenyl rings are 21.8 (3) and 41.8 (3)°.
Highlights
C26H24BrN3O2, the isoxazolidine ring adopts an envelope conformation, the ring N atom deviating from the mean plane of the other four atoms by an angle of
The orientation of the phenyl ring is +sp and the bromophenyl ring is +sc relative to the attached pyrazole ring; the dihedral angles between the least-squares planes of the pyrazole and the attached phenyl and bromophenyl rings are
Many pyrazole derivatives are known to exhibit a wide range of biological properties such as anti-hyperglycemic, analgesic, anti-inflammatory, anti-pyretic, anti-bacterial, hypoglycemic, sedative, hypnotic activity, and anticoagulant activity
Summary
S. Etti,a K. Karthikeyan,b G. Shanmugama* and P. T. Perumalb a Centre for Advanced Studies in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, India, and bOrganic Chemistry R factor = 0.036; wR factor = 0.096; data-to-parameter ratio = 17.2. In the title compound, C26H24BrN3O2, the isoxazolidine ring adopts an envelope conformation, the ring N atom deviating from the mean plane of the other four atoms by an angle of 0.286 . The orientation of the phenyl ring is +sp and the bromophenyl ring is +sc relative to the attached pyrazole ring; the dihedral angles between the least-squares planes of the pyrazole and the attached phenyl and bromophenyl rings are 21.8 (3) and 41.8 (3) . Data collection: APEX2 (Bruker, 2004); cell refinement: SAINT (Bruker, 1999); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to refine structure: SHELXL97 (Sheldrick, 1997); molecular graphics: PLATON (Spek, 2003); software used to prepare material for publication: SHELXL97 and PARST97 (Nardelli, 1995). SE thanks the Council of Scientific and Industrial Research (CSIR), New Delhi, for providing financial assistance as a Senior Research Fellowship (SRF).
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