Abstract
Carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM-1) is a transmembrane glycoprotein found on leukcocytes, endothelium, and epithelium, and its activation can attenutate colitis in murine models. Microarray analysis revealed that CEACAM-1 expression is increased during gut graft-versus-host-disease (GVHD). We studied the role of CEACAM-1 in a mouse allogeneic bone marrow transplantation model (B6→BALB/c]). Using CEACAM-1-/- mice as recipients or T cell donors caused sigificantly worse GVHD (p<0.05) compared to wildtype (WT) controls.
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