330. Association between maternal age and adverse outcomes in pre-eclampsia

Abstract

Introduction Studies have reported that women at more advanced maternal age are associated with a higher risk of developing pre-eclampsia and other pregnancy-related complications. However, fewer studies have explored the association of maternal age of women diagnosed with pre-eclampsia, with demographic characteristics, management and outcomes. Objective To examine pregnancy characteristics associated with maternal age for women admitted with pre-eclampsia and to compare the odds of increasing adverse maternal and perinatal outcomes with increasing age. Methods In total, 2427 women admitted with pre-eclampsia from 2003 to 2016 from tertiary hospitals in Canada, United Kingdom, Finland and USA were used for this study. Pregnancy characteristics were compared between women of 6 age groups: (i) Results Most women admitted with pre-eclampsia were between 30 and 34 years old. The gestational age at disease onset and blood pressure appeared to increase, while the prevalence of smoking decreased, as maternal age increased. Women at the extreme age groups ( Discussion Increasing maternal age was not associated with increased risk of adverse maternal or perinatal health outcomes for women admitted with pre-eclampsia. However, this study supports findings that maternal age is more strongly associated with late onset than early onset pre-eclampsia.