32P-chromic phosphate colloidal synovectomy combined with routine medication treating the hip disease of ankylosing spondylitis

Abstract

Objective To observe the therapeutic effect of 32P-chromic phosphate colloidal synovectomy combined with routine medication in the treatment of the hip disease of ankylosing spondylitis.Method Eight-two ankylosing spondylitis unilateral hip patients were divided into two groups.Forty-two were enrolled in the routine medication combined with 32P-chromic phosphate colloidal synovectomy group (treatment group) and 42 in conventional medicine group(control group).The efficacy and safety were observed.Resuts The effective rate of treatment group and control group were 73.8％ and 52.4％ respectively in the following six months.The difference was significant (x2=4.840,P＜0.05).The effective rate were respectively 53.8％ and 47.6％ in three-year follow-up,with no significant difference between the two groups (x2=0.047,P＞0.05 ).There was progress on the X-ray phases of hip joint in three-year follow-up,for the difference between the treatment group and the control group was significant (x2=5.516,P ＜0.05).During the different follow-up time,six months and three years,there were differences in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) before and after treatment between the treatment group and the control group,but the differences were not statistically significant ( t =1.303,t=1.759,P all＞0.05 ).When followed up for 6 months,the differences in the visual analogue scale(VAS) for hip of the treatment group and the control group were statistically different between before and after treatment(t=2.389,P＜0.05 ).But when followed up for three years,the differences were not statistically different (t=1.632,P＞0.05).The side effects was ob served only in five cases which was transient pain increase in joints.Conclusion 32P-chromic phosphate colloid synovectomy combined with routine medication had a short-term effect in treating the hip joint disease of ankylosing spondylitis. Key words: Spondylitis, ankylosing; Osteoarthritis, hip; Phosphorus radioisotopes; Synovectomy; Drug therapy; Chromic phosphate colloid