Abstract
Interleukin-12 (IL-12) is a potent antitumoral cytokine, but it can be toxic at high doses. In order to minimize side effects, we have optimized the Tet-on inducible system for liver-specific expression of murine IL-12 with reduced basal activity. The plasmid was transferred to mice by the hydrodynamics-based procedure and the antitumor effect of IL-12 was evaluated using two different animal models.
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