Abstract
Multiple studies across imaging modalities suggest the insula has a key role in pain processing. Recent work using functional connectivity MRI (fcMRI) during painful and innocuous thermal stimulation demonstrated anatomically different connectivity: the anterior insula (aIns) was more strongly correlated to the anterior cingulate cortex (ACC), while the posterior insula (pIns) better correlated to the primary somatosensory (S1) and motor (M1) cortices. Similarly, our prior work showed altered connectivity of the pIns to default mode network (DMN), and the posterior cingulate cortex (PCC) in particular, during painful acute electric nerve stimulation versus rest.
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