Abstract
The long term cultures of human lymphoblast cell lines provide an excellent source for the study of certain biologically active, soluble factors produced by lymphoid cells, such as migration inhibitory factor, lymphotoxin, and others. Additional factors that have been recently found are the inhibitor of nucleic acid synthesis and a non-specific mitogen. These factors were discovered during attempts to determine whether the original donors of lymphoblast cell lines, derived from normal individuals and from individuals having infectious mononucleosis, were stimulated by their own long term cell lines. As the experiments eventually evolved, supernatants from these cell lines were incubated with the original donor's peripheral leucocytes. Depending upon the culture conditions, either marked inhibition or stimulation was observed as detected by the incorporation of 3H-thymidine or uridine.
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