Abstract

The outer membrane of Escherichia coli contains a variety of pore-forming proteins called porins. These proteins have similar molecular weight and amino acid composition, but have substantially different chemical specificities for restricting free diffusion of aqueous solutes. One porin, called PhoE, is preferentially expressed under growth conditions involving phosphate starvation. PhoE porin serves not only as a nonspecific channel for small solutes, but also facilitates the diffusion of phosphate containing solutes as well as other negatively charged compounds.

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