Abstract
The one-pot synthesis of 3,6-bis(5’-bromo-3’-indolyl)-1,4-dimethylpiperazine- 2,5-dione is reported. Sarcosine anhydride is brominated and immediately reacted with 5-bromoindole to produce the product, which is characterized by 1H NMR, MS and microanalysis.
Highlights
Isolated from the marine sponge series Dragmacidin, Hexadella, and Spongosorites, unique bisindolylpiperazine alkaloids have received significant attention in recent years for their antiviral, cytotoxic, and anti-inflammatory properties [1–10]
Sarcosine anhydride is brominated and immediately reacted with 5-bromoindole to produce the product, which is characterized by 1H NMR, MS and microanalysis
The dragmacidin series of alkaloids each contain a central piperazine ring with indole units attached at the 2- and 5- positions
Summary
Isolated from the marine sponge series Dragmacidin, Hexadella, and Spongosorites, unique bisindolylpiperazine alkaloids have received significant attention in recent years for their antiviral, cytotoxic, and anti-inflammatory properties [1–10]. Abstract: The one-pot synthesis of 3,6-bis(5’-bromo-3’-indolyl)-1,4-dimethylpiperazine2,5-dione is reported. Sarcosine anhydride is brominated and immediately reacted with 5-bromoindole to produce the product, which is characterized by 1H NMR, MS and microanalysis. The dragmacidin series of alkaloids each contain a central piperazine ring with indole units attached at the 2- and 5- positions.
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