Abstract
Two dimensional single-crystal hexagonal gold nanosheets (SCHGNSs) were prepared by microwave heating of a solution of HAuCl4 in an ionic liquid. The SCHGNSs were characterized by field emission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, atomic force microscopy and electrochemical impedance spectroscopy. The SCHGNSs were then used to modify a graphite paste electrode for voltammetric determination of the hypertension drug captopril (CAP). The modified electrode showed a well-defined oxidation peak (at 0.41V vs. Ag/AgCl) at pH7.0 using differential pulse voltammetry. Under the optimum conditions, the response is linear in the 2-400nM and 4.0-50μM CAP concentration range, and the detection limit (at S/N= 3) is 0.3nM. The sensor was successfully applied to the determination of CAP in pharmaceutical tablets and in spiked urine. Graphical abstract Schematic presentation of the preparation of single crystal hexagonal gold nanosheets and theiruse to modify acarbon paste electrode for ultra-trace voltammetric determination ofthe drug captopril.
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