Abstract
Objective: Global cardiovascular risk stratification is essential in high-risk hypertensive patients. However, it is uncertain how often the strategy is executed in real clinical practice. We sought to evaluate the management of cardiovascular risk in hypertensive patients with coronary artery disease (CAD) using brachial-ankle pulse wave velocity (baPWV).Design and method: A total of 851 hypertensive patients with CAD (age 65 ± 11) were enrolled and baPWV were measured every year (mean follow up periods 4.5 years). All subjects were devided into two groups: optimal medical therapy group (systolic blood pressure<130mmHg, LDL-cho<100 mg/dl and HbA1c<7.0%) and sub-optimal therapy group. Results: In optimal medical therapy group, change of baPWV/year were significantly lower than in sub-optimal therapy group (p < 0.05) (figure). Conclusions: These results suggest that combination of optimal medical therapy is essential in management of high-risk hypertensive patients, and it might also reduce cardiovascular risk.
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