294: Outcome of Pregnancy with Metformin on Patient with Recurrent Spontaneous Abortion who Have Abnormal Carbohydrate Metabolism

Abstract

To determine the incidence of abnormal glucose tolerance test (GTT) in recurrent spontaneous aborters including PCO and non-PCO patients, and also whether metformin would safety reduce the rate of first trimester spontaneous abortions without teratogenisity in patients with abnormal GTT. Prospective pilot study. University related clinic. One hundred sixty-two patients with history of recurrent spontaneous abortions and 74 patients with previous term deliveries as control. Performing GTT on all patients administering metformin 1500 mg/day in patients with abnormal GTT. Continuation of pregnancy above first trimester. Out of 162 patients with previous abortions 29 (17.9%) and out of 74 women in control group, 4 (5.4%) patients had abnormal GTT respectively (p=0.017). Also 7 (24.1%) women in abnormal GTT group and 8 (6.1%) in normal GTT group were PCO. Among 29 patients with abnormal GTT, 17 patients were given metformin and 12 women receive nothing during pregnancy. Pregnancy outcome: Three of 17 (17.64%) patients in metformin group and 8 of 12 (66.6%) patients group II (non metformin group) aborted before 13 weeks respectively (p=0.04). No anomaly was seen in newborn of patients when delivered at term. It was shown that there is association between abnormal GTT and history of recurrent abortion including PCO and non PCO patients. Also improved outcome of pregnancy was seen with metformin therapy among those with abnormal GTT.