276 - Lipid peroxidation parameters in different stages of stress-reaction at the inherited stress-induced arterial hypertension rats

Abstract

Chronic stress plays significant role in the development of arterial hypertension. So, the studies of the various regimes of stress factors influence on the blood biochemical parameters are important. The aim of this study was changes in the reactions of lipid peroxidation and antioxidant defense parameters evaluation in rats of the ISIAH line. The investigation design consisted of the biochemical parameters assessing at the stage before the stress action (10 rats), and at the various stages of the stress response: anxiety (20 rats) and (20 rats). The 3-hour single immobilization of the animal on the back model used. As a result of the analysis of the experimental data, an increase in the intensity of the antioxidant defense system in rats of the ISIAH line was shown in the form of an increase in the level of total antioxidant activity and superoxide dismutase activity at the stage of anxiety, followed by a decrease in the functioning of these factors in the resistance stage. This fact can be related to the dynamics of blood pressure, the values of which in animals changed depending on the post-stress stage. Elevated values of blood pressure in the stage of resistance probably contributed to the development of negative changes at the local level in the form of a decrease in the intensity of nonspecific reactions of the stress-limiting system of antioxidant defense.