Abstract
BackgroundThe comparatively low 25 hydroxyvitamin D [25(OH)D] levels have been reported in patients with metabolic syndrome (MetS). Herein we investigated the cross-sectional and longitudinal relationships between serum 25(OH)D levels and MetS risk profile in northern middle-aged Chinese subjects without vitamin D supplementation.MethodsA cohort of 211 participants including 151 MetS patients and 60 controls at 20–69 years of age were enrolled from suburban Beijing, China. The recruited MetS patients were subjected to diet and exercise counselling for 1-year. All subjects at baseline and MetS patients after intervention underwent clinical evaluations.ResultsSerum 25(OH)D levels were significantly decreased in MetS patients. 25(OH)D levels were inversely related to MetS score, fasting blood glucose (FBG) and triglyceride-glucose index (TyG) after adjusting for cofounders (all P < 0.05). Participants in the lowest tertile of 25(OH)D levels had increased odds for MetS (P = 0.045), elevated FBG (P = 0.004) in all subjects, and one MetS score gain in MetS patients (P = 0.005). Longitudinally, the metabolic statuses as well as 25(OH)D levels of MetS patients were significantly improved (all P < 0.05), and the increase of 25(OH)D levels were inversely related to MetS scores, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), FBG, and TyG, while positively related to high-density lipoprotein cholesterol (HDL-C) after adjusting for confounders.Conclusions25(OH)D levels were significantly decreased in MetS patients, and it was negatively associated with metabolic dysfunctions at baseline and 1-year after. Metabolic aberrations of MetS patients were significantly ameliorated with 1-year follow-up counselling accompanying by notably elevated 25(OH)D levels.
Highlights
Vitamin D is a crucial family of fat-soluble secosteroids which plays a vital role in regulating calcium and phosphate homeostasis in vivo
The inclusion criteria were as follow: (1) Annual income, nationality and lifestyle were matched with the patients in the Metabolic syndrome (MetS) group; (2) Body mass index (BMI) < 28 kg/m2; (3) Waist circumstance < 80 cm for females, < 90 cm for males; (4) Fasting blood glucose < 6.1 mmol/L; (5) Systolic blood pressure (SBP) < 135 mmHg, diastolic blood pressure (DBP) < 85 mmHg; and (6) Serum triglycerides < 1.7 mmol/L
In our present study, we found that serum 25(OH)D levels were significantly decreased in MetS patients, and inversely associated with MetS and its components both cross-sectionally and longitudinally in northern Chinese middle-aged subjects without vitamin D supplementation
Summary
Vitamin D is a crucial family of fat-soluble secosteroids which plays a vital role in regulating calcium and phosphate homeostasis in vivo. Vitamin D deficiency, characterized by serum 25 hydroxyvitamin D [25(OH)D] levels ≤ 20ng/mL, is highly prevalent worldwide. Due to highly overlapped risk factors (inadequate exercise, lack of sun exposure, etc.), increasingly abundant evidences associating vitamin D deficiency and MetS and its components were emerging over the years [5, 8, 9]. Activation of VDR prevented pathological dedifferentiation of pancreatic beta cells [11], and downregulation of VDR increased endothelial inflammatory response in preeclampsia [12], further shed light on the potential associations between vitamin D and MetS. The comparatively low 25 hydroxyvitamin D [25(OH)D] levels have been reported in patients with metabolic syndrome (MetS). We investigated the cross-sectional and longitudinal relationships between serum 25(OH)D levels and MetS risk profile in northern middle-aged Chinese subjects without vitamin D supplementation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
