Abstract
The pharmacokinetics, tissue distribution, and excretion of 2,4-dichlorophenoxyacetic acid (2,4-D) were examined in channel catfish after intravascular or oral administration (10 mg/gg of body weight). Plasma concentrations of parent 2,4-D exhibited a rapid, biphasic decline after intravascular administration with an elimination half-life of 0.76 h. After oral dosing, 2,4-D was rapidly and extensively absorbed; the absorption half-life was 1.5 h, and the bioavailability was 86%
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