231 Efficacy of Mycotoxin Mitigation Product Containing Yeast Extract on Intestinal Health and Growth of Newly Weaned Pigs Under Chronic Dietary Challenges of Fumonisin and Aflatoxin

Abstract

Abstract This study aimed to investigate the efficacy of mycotoxin mitigation product containing yeast extract on intestinal health and growth of newly weaned pigs under chronic dietary challenges of fumonisin and aflatoxin. Newly weaned pigs (n = 48; 21 days old; 6.4 ± 0.3 kg BW) were allotted to 4 treatments based on randomized complete block design with initial BW and sex as blocks and fed for 32 d in 3 phases (P1/2/3 for 11/11/10 days, respectively). Dietary treatments were CON: control diet containing conventional corn; MT: CON with naturally contaminated corn (fumonisin at 8 mg/kg and aflatoxin at 0.19 mg/kg); CD1: MT with 0.2% of mycotoxin mitigation product (BG-MAX, Church & Dwight, Trenton, NJ); and CD2: MT with 0.4% of mycotoxin mitigation product. All diets were formulated to meet the nutrient requirements suggested by NRC (2012). At the end of study, all pigs were euthanized to collect jejunal tissues to measure TNF-α, IL-8, Immunoglobulins (IgG and IgA), malondialdehyde, protein carbonyl, and gene expression of tight junction proteins. Data were analyzed using MIXED procedure in SAS. Pigs in MT had less (P < 0.05) ADFI (406 to 503 g/d) and tended to have less (P = 0.051) BW (15.2 to 17.1 kg) and (P = 0.050) ADG (281 to 340 g/d) compared with CON during overall period. Pigs in MT had a lower (P < 0.05) G:F (0.22 to 0.74) and tended to have a greater (P = 0.071) fecal score (4.34 to 3.93) during phase 1. Increasing supplementation of mycotoxin mitigation product tended to linearly increase (P = 0.056) BW (15.2 to 17.0 kg), (P = 0.060) ADG (281 to 337 g/d), and (P = 0.066) ADFI (406 to 478 g/d) of the pigs during overall period. Increasing supplementation of mycotoxin mitigation product tended to linearly increase (P = 0.064) G:F (0.22 to 0.73) during phase 1. Increasing supplementation of mycotoxin mitigation product linearly decreased (P < 0.05) fecal score (4.34 to 3.87, 3.30 to 2.86) during phase 1 and 2. Increasing supplementation of mycotoxin mitigation product tended to linearly increase (P = 0.050) the concentration of TNF-α (5.49 to 7.11 pg/mg of protein) and decrease (P = 0.060) the concentration of IgA (6.29 to 3.23 mg/mg) in jejunum of the pigs. Increasing supplementation of mycotoxin mitigation product tended to linearly increase (P = 0.082) CL-1 expression (1.01 to 1.78) in jejunum of the pigs. In conclusion, supplementation of mycotoxin mitigation product containing yeast extract could mitigate the detrimental effects of mycotoxins on growth performance of newly weaned pigs, which might be contributed by improved the integrity and positively modulated immune response in the jejunum.