224 Epidemiology of juvenile systemic lupus erythematosus in 2016–2017: incidence, prevalence and age of onset

Abstract

Background The epidemiology of juvenile systemic lupus erythematosus (jSLE) varies among ethnic groups and countries and up-to-dated results on Asian population are not recently reported. The purpose of the present study was to investigate the prevalence and incidence of jSLE in Korea. Methods Data were collected from the exclusive national health claims database of Korea, which is covering more than 95% of the patient population. JSLE was identified using the diagnostic code M32 from the Korean Standard Classification of Diseases. Patients under 18years-old, who had at least one claim for jSLE between January 2016 to December 2017 as a primary or secondary final diagnosis were included in the study. Data encompass both outpatient and hospitalization records. SAS 9.4 and R package was used in data extraction and cleaning. Results We estimated sex- and age-specific prevalence and incidence of jSLE during the period. The prevalence of jSLE (95% CI) decreased from 5.85 (5.845.87) per 1 00 000 persons in 2016 to 5.35 (5.345.37) per 1 00 000 persons in 2017. The incidence of jSLE (95% CI) was 2.20 (2.192.21) per 1 00 000 persons in 2017. The prevalence and incidence of jSLE were higher in women than in men (4.87 per 1 00 000 in men vs.42.32 per 1 00 000 in female in prevalence of 2016, 2.74/100,000 in men vs. 10.00/100,000 in women in incidence of 2017). By change point analysis, female age of 13 in incidence and 15 in prevalence was detected as a uprising age. Conclusions The prevalence of jSLE in Korea was lower than Hawaiian natives and comparable with Canadian, Taiwanease and Japanease. Female with post-pubertal age was detected as a population of increasing change point. Funding Source(s): None