22 CHANGES OF THE BLADDER FUNCTION AFTER SPINAL CORD INJURY CAN BE ATTENUATED BY TAMSULOSIN TREATMENT IN RAT MODEL

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research I1 Apr 201222 CHANGES OF THE BLADDER FUNCTION AFTER SPINAL CORD INJURY CAN BE ATTENUATED BY TAMSULOSIN TREATMENT IN RAT MODEL Dong Han, Moon Young Lee, Hee Jong Jeong, Jeong Sik Rim, and Min Cheol Joo Dong HanDong Han iksan, Korea, Republic of More articles by this author , Moon Young LeeMoon Young Lee iksan, Korea, Republic of More articles by this author , Hee Jong JeongHee Jong Jeong iksan, Korea, Republic of More articles by this author , Jeong Sik RimJeong Sik Rim iksan, Korea, Republic of More articles by this author , and Min Cheol JooMin Cheol Joo iksan, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.065AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To investigate whether the hyperactivity of the bladder caused by spinal cord injury can be attenuated or not by tamsulosin, is an alpha-blocker that works by relaxing the muscles in the bladder. METHODS Forty eight Sprague-Dawley rats were divided into 3 groups: the control (CON), the SCI (SCI) and the SCI with tamsulosin treatment group (SCI+TAM). A spinal cord transection was performed surgically at the T10 vertebral level. Tamsulosin was injected intraperitoneally at doses of 1 mg/kg which was dissolved in distilled water once every morning for a week in the SCI+TAM group. After 1 week, in a part of the animals, continuous filing cystometry was performed in conscious animals 2 days after the bladder catheter implantation in both group of rats and basal pressure (BP), maximal voiding pressure (MVP), micturition duration time (MDT) and micturition interval time (MIT) was measured in each rat. In the other animals, the whole bladder was removed after decapitation as fastly as possible and used for in vitro organ bath study. RESULTS The percent changes in contractility from baseline after Ach treatment alone, Ach with muscarinic (M) 2 receptor blocker (AQ-RA741) pretreatment, and Ach with M3 receptor blocker (4-DAMP) pretreatment were compared between groups. In conscious cystometry study, compared to the CON group, all parameters are significantly changed in SCI and SCI+TAM group (p<0.05). However, there was also a significant increase in micturation duration time in SCI+TAM group compared to the SCI group (p<0.05) In the organ bath study, acetylcholine-induced contractility in the SCI and SCI+TAM group was significantly higher than that in the CON group (p<0.05). However, there was a significant decrease in Ach-induced contractility in SCI+TAM group compared to the SCI group. Additionally, there was also a significant decrease in Ach-induced contractility under 4-DAMP pretreatment in SCI+TAM group compared to the SCI group. CONCLUSIONS These results suggest that the hyperactivity of the bladder after SCI can be attenuated by tamsulosin treatment. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e8-e9 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Dong Han iksan, Korea, Republic of More articles by this author Moon Young Lee iksan, Korea, Republic of More articles by this author Hee Jong Jeong iksan, Korea, Republic of More articles by this author Jeong Sik Rim iksan, Korea, Republic of More articles by this author Min Cheol Joo iksan, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...