Abstract
Most female carriers of germline BRCA1 mutation develop breast/ovarian cancer during the lifetime. However, the penetrance of BRCA1 pathogenic variants does not reach 100%, and the age of BRCA1-associated breast cancer (BC) onset varies widely. BRCA1-driven tumors are chromosomally unstable and may have excessive antigenicity. We hypothesized that hereditary variations in immune response pathways may contribute to the variability of BRCA1 penetrance. We evaluated whether genetic variations in the immune response-related genes contribute to this heterogeneity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
