2103 THE USEFULNESS OF BASELINE PSA FOR PREDICTION OF RISK OF DEVELOPING PROSTATE CANCER IN KOREAN MEN LOWER THAN 70 YEARS OLD

Abstract

You have accessJournal of UrologyProstate Cancer: Detection and Screening IV1 Apr 20102103 THE USEFULNESS OF BASELINE PSA FOR PREDICTION OF RISK OF DEVELOPING PROSTATE CANCER IN KOREAN MEN LOWER THAN 70 YEARS OLD Kyung Kgi Park, Sang Un Park, Seung Hwan Lee, Dong Suk Kim, and Byung Ha Chung Kyung Kgi ParkKyung Kgi Park More articles by this author , Sang Un ParkSang Un Park More articles by this author , Seung Hwan LeeSeung Hwan Lee More articles by this author , Dong Suk KimDong Suk Kim More articles by this author , and Byung Ha ChungByung Ha Chung More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.2177AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recent studies have shown that prostate specific antigen (PSA) values can be used to predict risk of developing prostate cancer (PCa) in the future. Among western man in their 40s and 50s, a baseline PSA level above the median value for age is a stronger predictor of future risk of prostate cancer than family history or race. This current analysis aimed to validate the ability of baseline PSA to predict the future risk of PCa in a Korean population of men within a routine health checkup METHODS This is a retrospective analysis of men who had been invited to our institute for a routine health checkup between 2000 - 2004 with at least 4 years of follow-up data. Men 40 and <69 years of age, with a baseline PSA value between 0 - 4.0 ng/mL, not receiving 5-alpha reductase inhibitors were included. Men were followed for at least 4 years after their first PSA value. The risk of PCa diagnosis was evaluated based on a age specific median PSA value of korean men, and was assessed by logistic regression, controlling for age RESULTS A total of 6654 patients were included in the analysis. At baseline, patients had a mean age of 50 years and a mean PSA of 0.96 ng/mL. Mean follow up was 8.3 years. Age specific median PSA were 0.79 ng/ml in 40¡<>±s, 0.81 ng/ml in 50¡±s, 0.93 ng/ml in 60¡±s. Overall, 0.6% of patients with baseline PSA of more than age specific median were diagnosed with PCa after about 6.4 years, compared to 0.03% of patients with a baseline PSA of lower than age specific median. In a multivariate analysis (controlling for age), patients with a baseline PSA of more than median were 11.59 times more likely to be diagnosed with PCa over at least 4 years than patients with baseline PSA of lower than median (OR = 11.59; 95% CI: 1.5-90.2; p < 0.018) CONCLUSIONS This analysis validates that men with baseline PSA values between age specific median PSA and 4.0 ng/mL are at a significantly increased risk for developing future prostate cancer compared to those with a PSA value below the median. Despite of the low number of object and relatively short follow up time, baseline PSA may be used to estimate future risk of prostate cancer in Korean men. Seoul, Republic of Korea© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e817-e818 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kyung Kgi Park More articles by this author Sang Un Park More articles by this author Seung Hwan Lee More articles by this author Dong Suk Kim More articles by this author Byung Ha Chung More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...