Abstract
Bioactive derivatives of cholesterol have been demonstrated to regulate immune cell function and migration, the tumor microenvironment (TME), and consequently tumor progression. Ch25h, a key enzyme involved in cholesterol metabolism and 25- hydroxycholesterol(25-HC) production, was positively correlated with overall survival in melanoma, breast cancer and colon cancer patients. High Ch25h expression is correlated with good response to immunotherapy in melanoma and glioblastoma patients. Expression levels of Ch25h in human tumors are also positively correlated with lymphatic signature.
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