Abstract
The selective transport of molecules across membrane pores is an essential biological process that occurs in all living organisms. Examples include the chaperone of proteins and mRNA in and out the cell nucleus mediated by the nuclear pore complex and the transport of specific molecules across a biological membrane mediated by active and passive transporters. Here, I describe an artificial DNA transporter that is formed by incorporating a DNA carrier element into a biological nanopore imbedded in a lipid bilayer. This device is able to transport specific DNA strands across a biological membrane mediated by a simple reaction mechanism based on DNA strand displacement. Similar to biological secondary active transporters, this system uses an electrochemical potential difference to pump a specific substrate across a biological membrane at a constant transmembrane potential. Our DNA actuator might be used to separate or concentrate nucleic acids, or to vehicle genetic information across the biological membranes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
