Abstract
Introduction: Necrotizing enterocolitis (NEC) is a severe intestinal inflammatory disorder characterized by increased circulating endotoxin (LPS) and apoptosis of ileal enterocytes. Heat shock protein 70 (Hsp70) is a molecular chaperone that prolongs cellular survival, although a role in enterocyte apoptosis remains ill defined. We have recently shown that the TLR9 agonist CpG-DNA is protective against LPS-induced apoptosis, although the mechanisms involved remain unclear. We now seek to determine whether CpG-DNA acts via the up-regulation of Hsp70, and whether CpG-DNA may have a protective role in the treatment of NEC.
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