Abstract
Publisher Summary We are challenged with new ways to deal with data accuracy, sequence redundancy, inconsistent nomenclature, and functional classification. The best way to facilitate progress in this area is to devise new tools and data representations that allow the community to carry out this work. These include databases that allow complex queries against the data, as complements to databanks that now archive deposited sequences. This chapter discusses the development of The Institute for Genomic Research (TIGR, Rockville, MD), the TIGR Database (TDB) as a collection of tools and databases designed to facilitate discovery in biology. It presents the TIGR databases as a collection of unique databases having a robust representation of sequences and associated information. The databases have consistent semantics and nomenclature, minimized redundancy compared with sequence archives, and persistent unique identifiers for the data, allowing extensive links to be established among the data. These databases play a key role in the analysis and interpretation of data from DNA sequencing projects in many species.
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