Abstract
ObjectiveThe objective of this study was to develop genetically modified probiotic E. coli Nissle 1917 (EcN-23) slowly releasing 2-ketogluconic acid (2-KG) asa chelator and pyrroloquinoline quinone (PQQ) as an antioxidant against heavy metal induced damage. MethodsMale rats were exposed separately to cadmium (Cd), mercury (Hg), lead (Pb) for amonth and Cd-Pb together for 4months. ResultsEcN-23 significantly decreased oxidative stress induced by Cd and Hgas compared to orally given PQQ and 2-KG and also prevented LPS induced damage in Pb treated rats along with enhanced gastric emptying and survival. Moreover, oxidative damage, histopathological damage and dislipidemia markers were maintained at near normal in rats on long term coexposure of Cd and Pb without any loss in essential metal ions. ConclusionTreatment of EcN-23 is effective against Cd, Pb and Hg toxicity as well asCd and Pb coexposure.
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