2.1 Change in Body Weight After 24 Weeks of Vildagliptin Therapy as a Function of Baseline Glucose Levels in Patients with Type 2 Diabetes (372-OR)

Abstract

Overall, treatment with DPP-4 inhibitors is weight neutral. However, from lower baseline levels of glycemia it was reported that vildagliptin therapy results in > 1 kg weight loss over a 2 year period. We hypothesize that when weight change is correlated with baseline fasting plasma glucose (FPG), patients with FPG above the renal threshold would be associated with positive caloric balance and those below the renal threshold with negative caloric balance.