Abstract
Zonula occludens-1 (ZO-1) is an epithelial junctional protein that participates in adherens junctions (AJs) and tight junctions (TJs). In simple epithelia, ZO-1 localization shifts from AJ to TJ during the maturation of cell adhesion. We recently showed that ZO-1 is more multilayered in buccal mucosa than in skin. However, what causes this difference and how ZO-1 is spatially regulated have not been elucidated. Here we show that epithelial turnover and proliferation dictate ZO-1 distribution in the squamous epithelia.
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