Abstract
Peroxides contaminating parenteral nutrition (PN) are associated with oxidized redox potential of glutathione in blood of preterm newborns ( Methods At day 3 of life, through a jugular catheter, guinea pigs (N=55) received PN (dextrose, amino acids, lipids, vitamins, electrolytes) enriched in glutathione (0, 50, 120, 165, 270, 370, 650 μg GSSG/kg/d). A control group (no manipulation, fed by mouth) served as reference. After 4 days, lungs were taken for determination of GSH, GSSG, redox potential (capillary electrophoresis) and alveolarization index (AI) (number of intercepts between a 1 mm line and histological structures). Data (mean ± sem) from animals on PN were compared by ANOVA, p Results The low AI observed with low doses (μg/kg/d) of GSSG (0-120: 26±1) was corrected with higher level (165-650: 30±1, p Conclusion Addition of glutathione into PN allows detoxification of peroxides (lower GSSG), preventing oxidation of redox and loss of alveoli. Our team is funded to start a clinical study soon.
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