Abstract

Hyperthermia (HT) treatment involves exposing a part of the body to elevated temperatures to achieve significant therapeutic effect. The use of magnetic nanoparticles to create therapeutic HT is known as magnetic hyperthermia (MHT) therapy. HT has been studied for decades for its anti-cancer properties and its potential as a treatment for cancer. Techniques used to achieve local hyperthermic effects include radiofrequency, ultrasound, microwave, laser, and magnetic nanoparticles. However, despite more recent advances, MHT has not yet become part of cancer treatment care standards. Some challenges, such as accurate thermometry of tumor mass and accurate tumor heating, prevent its widespread use as a treatment for cancer. Its therapeutic efficacy, technical details, and major experimental and clinical findings have been reviewed and analyzed. Finally, there is an in-depth discussion on current limitations, areas for improvement, and future directions. This chapter summarizes the latest technologies and focuses on the advantages and challenges of the three major nanoparticle formulations in focus: superparamagnetic metal oxide nanostructures.

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