Abstract
This study reports the synthesis and characterization of N-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl-4-[ 18F]fluorobenzamide ([ 18F]MPP3F). The total reaction time for [ 18F]MPP3F, including final high-performance liquid chromatography purification, was about 3 h. Typical decay-corrected radiochemical yield was 18.4±3.1%. The radiochemical purity was >98%. Biodistribution in mice showed that [ 18F]MPP3F is a potential brain imaging agent for positron emission tomography. The brain uptake of [ 18F]MPP3F was 6.59±0.77% Injected Dose/g at 2 min post-injection time. A brain-to-blood ratio of 3.67 was reached at 15 min after injection.
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