Abstract
Significant renal mass reduction induced by 5/6 subtotal nephrectomy is associated with a chain of events that culminates in hypertension and chronic kidney disease (CKD). The leading cause of death in CKD is cardiovascular diseases. Angiotensin type 1 receptor (AT1R) is thought to play a role in progression of the disease and development of complications because of the beneficial effect of AT1R blockade. However, conflicting results were reported on intrarenal AT1R levels in CKD models. Noninvasive imaging will allow for identification of receptor expression abnormalities, understanding the contribution of the AT1R to the progression of disease and will aid to guide medication.
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