Abstract
Hypoxia is prevalent in solid malignant tumors and linked to angiogenesis. Uncoordinated expression of angiogenic factors results in dysfunctional blood vessels and promotion of metastasis, associated with poor prognosis. VEGFA, a main driver of angiogenesis, has been proven to be an efficacious target in multiple malignancies. Based on known hypoxia-regulated genes, a score of hypoxia response was established to rank various tumor types according to the magnitude of hypoxia response. It was further used to interrogate whether hypoxia response is linked to patient prognosis.
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