1662 LOWER URINARY TRACT DYSFUNCTIONS AND UPPER URINARY TRACT FUNCTION IN PATIENTS WITH MULTIPLE SCLEROSIS (CLINICAL, NEURO-IMAGING AND URODYNAMIC STUDY)

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Neurogenic Voiding Dysfunction1 Apr 20121662 LOWER URINARY TRACT DYSFUNCTIONS AND UPPER URINARY TRACT FUNCTION IN PATIENTS WITH MULTIPLE SCLEROSIS (CLINICAL, NEURO-IMAGING AND URODYNAMIC STUDY) Hosni Khairy Salem, Mona Nada, Abd El Azim Reda, Mohammed El Saeid, and Adel Gad Hosni Khairy SalemHosni Khairy Salem Cairo, Egypt More articles by this author , Mona NadaMona Nada Cairo, Egypt More articles by this author , Abd El Azim RedaAbd El Azim Reda Cairo, Egypt More articles by this author , Mohammed El SaeidMohammed El Saeid Cairo, Egypt More articles by this author , and Adel GadAdel Gad Cairo, Egypt More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1494AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of this study is to determine the voiding dysfunction secondary to MS and its relations to various clinical and radiological characteristics of the disease, and also upper urinary tract (UUT) complications in MS. METHODS This study included 40 patients with clinically definite MS. Based on the course of the disease, two groups were identified: Group I: included 20 patients with relapsing remitting MS (RRMS). Group II: included 20 patients with secondary progressive MS (SPMS).All patients submitted to a urological history, general medical examination, neurological examination, laboratory investigations, MRI, ultrasound, ascending cystography and Urodynamic assessment. Expanded disability status scale (EDSS) and Functional assessment score of multiple sclerosis (FAMS) were used to quantify the disability in MS and quality of life (QOL) respectively. RESULTS Intermittency was the most common urinary symptom (42.5%) particularly in patients with pyramidal tract affection (45.71%). Urodynamic abnormalities were found in 100% of MS patients. Detrusor overactivity was the most frequent urodynamic finding. Detrusor overactivity >40 cm H2O was found to be significantly more frequent in group II patients (P< 0.05). The UUT involvement in MS patients was 12.5%, all affected patients were limited to group II. FAMS scores were significantly lower in group II (p < 0.05) while EDSS scores were significantly higher in group II (p < 0.05). CONCLUSIONS Lower urinary symptoms (LUTS) were highly prevalent in MS patients, mostly voiding symptoms (intermittency, straining). Detrusor overactivity was the most common urodynamic finding in patients with MS. UUT complications in patients with MS were 12.5% and were limited to progressive category (SPMS). © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e671 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Hosni Khairy Salem Cairo, Egypt More articles by this author Mona Nada Cairo, Egypt More articles by this author Abd El Azim Reda Cairo, Egypt More articles by this author Mohammed El Saeid Cairo, Egypt More articles by this author Adel Gad Cairo, Egypt More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...