Abstract
Trough- or 2-hour post dose (C2) blood cyclosporine (CyA) concentrations are used for prediction of efficacy and toxicity of CyA in transplant recipients. Data on CyA concentrations in the target organ –lymphocytes and natural killer cells- is very sparse. Everolimus is increasingly being used in cardiac transplantation. Because of the inhibitory effect of everolimus on the drug efflux pump present in lymphocytes, we hypothesized that CyA pharmacokinetics in blood and lymphocytes were dissociated in patients concomitantly treated with everolimus.
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