Abstract
Disorganized attachment is an important risk factor for socio-emotional problems from childhood to adulthood. Prevailing models of the etiology of disorganized attachment emphasize the role of dysfunctional parenting at the exclusion of complex models examining the interplay of child and environmental factors. The long-term effect of birthweight on child development is consistent with prenatal programing hypothesis. Dopaminergic activity is a potential moderator with consistent evidence for the dopamine Receptor D4 (DRD4) and less for dopamine active transporter 1 (DAT1), brain-derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT). We examined two- and three-way interactions between child dopaminergic polymorphisms, birthweight, and maternal caregiving at age 6 months in the prediction of disorganized attachment at 36 months.
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Schedule a callMore From: Journal of the American Academy of Child & Adolescent Psychiatry
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