Abstract
Energy imbalance is one of the tumor cells' key properties in some cases supporting rapid progression and resistance to therapies. Simultaneous effects on glycolysis and other signaling pathways seem to be a promising strategy for anticancer therapy. Objectives: evaluation of the effects of glucose deprivation and glycolysis inhibitor (2-Deoxy-D-Glucose, 2DOG) on the antiproliferative activities of various anticancer agents, searching for promising combinations.
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