Abstract
Synaptic loss produced as a consequence of chronic stress contributes to the emergence of depressive-like behavior in animals. Reduced synaptic density and deficits in cortical functional connectivity are also hypothesized to contribute to symptoms associated with major depressive disorder (MDD) and posttraumatic stress disorder (PTSD). We can now quantify synaptic density in vivo by measuring synaptic vesicle glycoprotein 2A (SV2A) with the radioligand [11C]UCB-J and positron emission tomography (PET).
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