Abstract
groups: (1) control, saline-treated group (n = 16), (2) dimethylsulfoxide-treated group (n = 16), (3) group that received lindane, dissolved in dimethylsulfoxide, in a dose of 8 mg/kg intraperitoneally (n = 16). Eight animals from each group were sacrificed 0.5 and 4 h after treatment and brain samples were prepared for further analysis. Acetylcholinesterase activity (mitochondrial and synaptosomal fraction) was determined in cerebral cortex, thalamus, hippocampus and nc. caudatus spectrophotometrically. Results: A significant rise in mitochondrial acetylcholinesterase activity was detected in cortex and nucleus caudatus of lindane-treated animals 0.5 h after administration (p < 0.05). This rise was sustained in nucleus caudatus within 4 h after treatment (p < 0.05). In contrast, activity of synaptosomal acetylcholinesterase fraction was significantly increased only in thalamus 4 h after lindane administration (p < 0.05). Conclusion: An increase in acetylcholinesterase activity may be involved in mediating acute neurotoxic effects of lindane, at least in some brain structures in rats.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
